Holly Turner and Allie Panara added two goals and an assist apiece.
Pittsford led 9-3 early in the second half before Lancaster closed within 11-7. However, Christine Molinari, Panara and Culligan each scored to seal the win.
The Panthers move on to Friday's state semifinal against West Genesee from Syracuse's Section Three. The game will be played at SUNY Cortland with faceoff at 2:30pm.
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