Emma Guy added a double-double with 14 points and 11 boards.
The Blue Devils played Penfield tight in the first half, trailing by four after the first quarter and by just 13 at the half. However, the Patriots outscored Victor 34-12 in the second half.
Fran Valenti led Victor with 12 points while Kate Leonard scored 10.
Penfield moves on to face (4)Gates-Chili in Monday's semifinals at Pittsford Sutherland. The Spartans beat (5)Hilton 59-54 behind 44 points by Cierra Dillard.
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