Brighton had the game tied late in the third quarter, but Irondequoit took over in the fourth and eventually built their lead to 15 points.
Courtney Clyburn led all scorers with 29 points for the Barons. Josh Hunt added 11 points, including three 3-pointers.
Dylan Harrington and Antonio McIntyre were also in double figures for the Eagles with 12 and 11 points, respectively.
Irondequoit improves to 12-1 while Brighton falls to 8-6.
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