Jen Reininger added nine points for the Eagles, who outscored Mendon 28-16 in the second half.
Alley Phillips led the Vikings with eight points.
Irondequoit improves to 11-3 while Mendon falls to 10-4.
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.