Lucy Covely led the Patriots with 17 points while Sheila Nesselbush added 12.
Candaisy Crawford had 14 points to top the Titans and Kara Houppert finished an impressive career with a 13 point game.
Penfield moves on to play the game that was expected to happen all year. Friday night, the Patriots will meet (1)Gates-Chili in the Class AA1 finals at Roberts Wesleyan. The Spartans romped past (5)Rush-Henrietta 59-33 Tuesday in the nightcap at Sutherland.