It happened around 4 p.m., Saturday.
Rochester Police say the man was going eastbound on Route 104 when he lost control of his motorcycle and crossed the medium, just before the concrete barrier.
He drove into the path of an oncoming car.
The driver of the car had minor injuries.
As of 6:30 p.m., Saturday, the westbound lanes of Route 104 are closed beginning at Hudson Avenue.
The accident is still under investigation.
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